Adrenal Gland Disease
What is it?
Adrenal disease is one of the most common illnesses of pet ferrets in North America, usually in ferrets over three. One or both adrenal glands become overactive, often from a tumor, and produce excess sex hormones.
What signs should I watch for?
Signs to watch for include hair loss starting at the tail and spreading; itchy skin; swollen vulva in spayed females; straining to urinate in males (EMERGENCY); and aggressive or sexual behavior, muscle loss.
How is it diagnosed and treated?
Diagnosis relies on signs, ultrasound of the adrenal glands, and sometimes hormone testing. Options include a hormone-suppressing implant and/or surgery to remove the affected gland.
Can it be prevented, and what's the outlook?
- Treatment should not be delayed; in males an enlarged prostate can block urination.
- Regular checkups help catch it early.
Reviewed by the Adler Veterinary Hospital veterinary team, October 2026.
Ferrets over three years old
Who's at risk:
Hair loss from the tail, itchy skin, swollen vulva
Main signs:
Schedule a visit soon
Urgency:
When to call a vet right away
- Straining to urinate (in males)
- Blocked urination from an enlarged prostate (in males)
Not sure whether it can wait? Call us anyway. Our team can help you decide.
Source:
Related conditions
Helicobacter Gastritis
Insulinoma
Lymphoma