Cushing's Disease
What is it?
Cushing's disease (hyperadrenocorticism) is overproduction of cortisol, the body's stress hormone. Most cases come from a small tumor in the pituitary gland; fewer arise in an adrenal gland. It mainly affects middle-aged and older dogs.
What signs should I watch for?
Signs to watch for include increased thirst, urination, and appetite; pot-bellied appearance; thinning hair, thin skin; heavy panting; and muscle weakness.
How is it diagnosed and treated?
Diagnosis uses blood work, urine tests, and special hormone stimulation or suppression tests, plus ultrasound of the adrenal glands. Most dogs are managed with daily medication and regular monitoring; some adrenal tumors are removed surgically.
Can it be prevented, and what's the outlook?
- Treatment usually improves comfort and controls signs.
- Regular rechecks are essential to keep therapy safe.
Reviewed by the Adler Veterinary Hospital veterinary team, October 2026.
Middle-aged and older dogs
Who's at risk:
More thirst, urination and appetite, pot belly, panting
Main signs:
Ongoing management with your vet
Urgency:
When to call a vet right away
- Drinking and urinating much more than usual
- Eating much more than usual
- Heavy panting
- Lethargy
- Skin or bladder infections that keep coming back
Not sure whether it can wait? Call us anyway. Our team can help you decide.
Source:
Related conditions
Addison's Disease
Diabetes
Hypothyroidism